The line "come rain, blood, or horse manure" is but a colourful variant of the idiom
come rain or shine:
no matter whether it rains or the sun shines; in any sort of weather
This one-off variant was coined by ABC president John B. Sias in 1987 after the yet-to-be-aired Amerika had generated more controversy and viewer response than any other ABC program in history, including The Day After. The miniseries took three years to make and cost nearly $40 million. The story was about the peaceful takeover of the United States by the Soviet Union with the complicity of international 'peacekeeping' troops, whose uniforms and insignia were similar to those of the U.N. forces.
Source: 'Amerika' Sponsor Chrysler Pulls Out. By New York Times
The full quote is as follows
It will not cripple us. It'll hurt us. But we're going to run that program come rain, blood or horse manure.
Using Google's wildcard search, the Ngram shows that the version with rain, blood, or manure is not a common saying nor idiom.
However, if the OP is curious to know, the earliest instance of "rain or shine" I found on Google Books is dated 1822 in
The Edinburgh Review Or Critical Journal
He who, secure within, can say,
To-morrow do thy worst, for I have lived to-day.
"Be fair or foul, or rain or shine,
The joys I have possessed, in spite of fate, are mine;
Not Heav'n itself upon the past has power,
But what has been, has been, and I have had my hour."