English is inherently ambiguous and no amount of punctuation can solve this. Ever notice that the examples on the internet showing how one style is better than the other are invariably contrived? In context we'd know things like whether Stalin and JFC are alive in the surrounding narrative or if a couple of strippers used the least alluring pseudonyms in history. Or, and hear me out, maybe the context is that JFC is the airport in NYC. I admit this is an unlikely possibility, but surely there's room in the universe of possible stories for locations to be personified, given agency and eligible to being invited to parties?
My personal style is to leave off the serial comma unless it clarifies. In the usual case, a comma substitutes for "and" in a list:
I like coffee and tea and chocolate.
becomes:
I like coffee, tea and chocolate.
In this case the Oxford comma would be superfluous because there's not much room for ambiguity. But consider a more complex sentence:
I relax and enjoy coffee, tea and chocolate.
In this case I use "and" to separate two halves of a sentence and as the final separator in my list of caffeine sources. I don't think these uses are particularly ambiguous, but the serial comma can help readers parse this sentence:
I relax and enjoy coffee, tea, and chocolate.
So why not use the serial comma every time you make a list of things? One reason is that nobody uses the comma for a list of two items: "tea, and chocolate". The ambiguity doesn't come from the comma or lack of comma, but from the different ways "and" is pressed into duty. It's a conjunction and the terminating separator in a list. The Oxford comma attempts to remove this ambiguity, but only if the list contains three or more items. For the vast majority of cases in typical usage, this is unnecessary and redundant.