Are the following two sentences interchangeable?
"Are you okay with that?"
"Is that okay with you?"
Are the following two sentences interchangeable?
"Are you okay with that?"
"Is that okay with you?"
Yes and No.
If you just want to be understood, then yes, go ahead and use them interchangeably.
If you want to show your English teacher that you understand the difference between subject and object, then unfortunately you'd fail at convincing her.
In this sentence,
"Are you okay with that?"
"You" is the subject and "that" is the object. Whereas, in this sentence,
"Is that okay with you?"
"That" is the subject (and therefore takes the singular verb "is" as opposed to those/these which would again take the plural verb "are") and "you" is the object.
I'm covering all of my bases with this answer, but sorry I can't give you a simply Yes or a simple No.