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What is the rule of pronunciation in this case? Why do we say like if there was an "e" in place of the "i"?

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    "e" instead of "i"? How do you think we pronounce it? I've only heard it as pronounced here (dih-zeez)
    – Kevin
    Commented Oct 21, 2013 at 1:01
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    English vowels in unstressed syllables (like the first syllable of disease) can have substantial variation depending on the dialect. Native English speakers generally don't hear this variation. I think most English speakers use either a schwa /ə/ or a short i /ɪ/. Is this difference what you're asking about? Commented Oct 21, 2013 at 1:19
  • @PeterShor - Yep thanks for clarifying, I didn't really now how to ask it correctly...
    – Matteo
    Commented Oct 21, 2013 at 5:53

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That's not how I pronounce it, and that's not the pronunciation recorded in my dictionary.

Which accent / dialect do you speak? It may be that the pronunciation in your speech community differs from the "standard" pronunciation in a systematic way, and that your observation about disease is an instance of this deviation.

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