@ColinFine got it right.
I don’t suppose you are coming, are you?
*I don’t suppose you are coming, aren't you?
The second one is ungrammatical. The first one is the way it should be.
That's the answer. Here's the reason why that's the answer.
There are two clauses in the original statement, with two verbs, suppose and come (which both occur with auxiliary verbs, but they're the clausal main verbs). The second clause you are coming is the direct object of the main verb suppose, and if there were no negatives, the tag question would be aren't you?
- I suppose you're coming, aren't you?
But there is a negative; it's I don't suppose. However, whatever rules you may think you know, there's none that produce the second example. It's unusual to make a tag question with a first-person subject
- I like roti canai, don't I?
- I don't like roti canai, do I?
but it's possible, if rare. So a tag question for
- I don’t suppose you are coming.
would be
- I don't suppose you're coming, do I?
which is odd (why don't I know what I suppose?), but grammatical.
The next problem is how to tag the downstairs verb. To do this you have to note that, with what are called Negative-Raising Predicates, including, but not limited to
- think, believe, suppose, imagine, expect, reckon, feel, guess, seem, appear, look like, sound like, feel like, be probable, be likely, figure to, want, intend, choose, plan, be supposed to, ought, should, be desirable, advise, and suggest,
negating the predicate in the upstairs clause is equivalent to negating the predicate in the downstairs clause. This is called Negative Raising -- the semantic result is that the negative originates downstairs and is moved to its place upstairs by rule, without changing meaning. But tags pay attention to meaning.
- She doesn't want to go == She wants not to go.
- It isn't likely she'll go == It's likely she won't go.
- I don't suppose you're going == I suppose you're not going.
And, since that last sentence means I suppose you're not going, therefore a correct reversing tag of the downstairs clause is a positive , are you?