The words meaningless, pointless, useless all have some degree of negative connotation to me as a non-native english speaker.
I'm trying to express that a certain configuration has no effect to a system at all. The sentence I am trying to use is: The configuration xyz is ... (without any effect).
Update: The negative connotation that I mean is what may be communicated inadvertently to the one that attempted to effect the system when he is told by the other that his configuration has no effect. I altered the title of the question to express where the negative connotation I meant referred to