You use paired commas to set off a parenthetical. > Findings show that there is increased blood flow to the brain. If you want to insert "during the initial stages of love" as a parenthetical, you set it off with commas, hence: > Findings show that<b>,</b> during the initial stages of love<b>,</b> there is increased blood flow to the brain. This has nothing to do with the fact that the parenthetical happens to be preceded by the word "that". For example: > Findings show, during the initial stages of love, there is increased blood flow to the brain. > > Findings show, during the initial stages of love, that there is increased blood flow to the brain. Notice the commas are still there, still setting off the parenthetical. These are a bit awkward, but still perfectly legal grammatically.