Let's say we have a guy who is stupid and weak and everybody picks on him and mocks him all the time. What would we call this guy?
I found timid in the dictionary but I am looking for a colloquial word.
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I found all of these in a thesaurus, under the entry for weakling:
pushover, namby-pamby, coward, milksop; informal wimp, weed, sissy, twinkie, drip, softie, doormat, chicken, yellow-belly, scaredy-cat, wuss
Based on your question, I'd recommend pushover or doormat from that list. Others might work better if you want to emphasize the person's weakness, as opposed to their status as a perpetual victim.
Wuss might work well, too; NOAD defines it as a weak or ineffectual person (often used as a general term of abuse).
How about schlemiel, a Yiddish loan word meaning an inept, clumsy, stupid person whom everyone picks on? It's only commonly used in the USA, however, in places with a strong Jewish influence.
"A person so inept even inanimate objects pick on them." (UD)
Indeed, his name derives from the Yiddish expression for "little man," and through much of the film Kleinman acts like the helpless schlemiel of Jewish humor, who is impotent before the overwhelming forces that assail him. (Self-knowledge and personal growth in Woody Allen's films …
Pee-on (slang): A person who is of such low status in society that it is socially acceptable for another person of higher status to pee on them.
Courtesy of Urban Dictionary.