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I'm writing an essay on how immigrants came to the US in the 1900s for salvation, but instead, they got the opposite. However, I'm looking for a more complex word; it'll sound boring if I just say it was the opposite of what they expected.

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Whereas the pilgrim fathers three centuries earlier may have sought religious salvation , many immigrants in the 1900s sought economic salvation: being saved from the economic dangers of starvation and unemployment.

salvation = being saved from danger, loss, or harm

Cambridge Dictionary

In your context, the appropriate antonym is therefore not religious but socio-economic.

Of the many words, I suggest privation

privation = a lack of the basic things that are necessary for an acceptable standard of living

Cambridge Dictionary

You might also consider destitution, indigence, poverty, and hardship.

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damnation: (in Christian belief) condemnation to eternal punishment in hell. (Lexico)

sins that risk eternal damnation

perdition: (in Christian theology) a state of eternal punishment and damnation into which a sinful and unpenitent person passes after death. (Lexico)

Hence, if the children suffer eternal perdition because their parents, who are themselves Christians, do not teach them how to attain salvation, God will judge and punish the parents.

reprobation: (Theology) the state of being damned (Collins)

Praise be to God,..who decrees election to some and reprobation to others.

doom: fate, lot, irrevocable destiny. (Usually of adverse fate; rarely in good sense); final fate, destruction, ruin, death. (OED)

Both the Cardinal and his enemies knew that the minister's doom was sealed.

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