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Something like the word 'antithesis', however instead of just meaning 'this is the opposite of that' I thought there was a word that meant 'doing this signals the death of this'.

I thought there was a word to describe this, but nothing comes to mind.

The meaning behind the phrase I'm thinking of is roughly 'if I accept to do this, it is the death of the purpose of my job'.

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    Do you require a word or longer expression? It's not clear. Mar 12 at 15:26
  • Are you talking about something like a Catch-22?
    – Joachim
    Jul 10 at 16:30
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I suggest

The final nail in the coffin

an event that causes the failure of something that had already started to fail: This latest evidence could be the final nail in the coffin for Jackson's case.

[Cambridge Dictionary]

Or perhaps, the words below sound more appropriate in the context you've provided (Apologies, I read the example you have provided after giving my first answer).

negate

to cause to be ineffective or invalid Alcohol can negate the effects of some medicines.

Thwart

to oppose successfully : defeat the hopes or aspirations of

[Merriam-Webster Dictionary]

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