The differences are the particle and the number.
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2We say "In most cases". – Old Brixtonian Jul 16 '20 at 14:39
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"Cases" is plural in the common expression "in most cases."
In most cases, the flu is not fatal.
That's a use of "cases" in the medical sense. Here is a more general example:
In most cases, I eat healthy food.
The phrase "in most cases" can often be replaced by the word "usually."