Can I use "color" in one paragraph, but write "colour" in the next one? Yes, I just did it. But is it acceptable to do so when not talking about spelling differences?
closed as off topic by FumbleFingers, aedia λ, Daniel, kiamlaluno, simchona Dec 20 '11 at 2:49
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The obvious reason to NOT used multiple different spellings is for consistency and to avoid confusion. If you write "color" in the first paragraph and "colour" in the second, a reader may well wonder if you are trying to make some point or just forgot what you were doing or can't make up your mind. At the very least, it would be distracting.
I can't think of any good reason TO do this. Well, other than because you are pointing out alternative spellings, or quoting from sources that use different spellings, or that sort of thing.
In the absence of a good reason to do it, and several good reasons not to do it, I would think you just shouldn't do it.
Neville Shute used to vary the spellings in his novels' dialog/ues depending on the nationality of the fictional character speaking.