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It's a single word. My explanation might be vague but I'll try my best to explain.

Basically, a person trying to achieve a goal but his _______ hinder him from attaining the said. It's sort of defect or problem (something they lack) which inevitably leads to failure.

2

Without more context its hard to say. "His flaws hinder him" works in a general sense, but if you want to be more specific, context is needed.

But speaking specifically to the 'lacking' aspect - perhaps deficiencies is a possible answer:

From Merriam-Webster:

: the quality or state of being defective or of lacking some necessary quality or element : the quality or state of being deficient : INADEQUACY

-1

This word doesn't fit into the sentence, but fits your other descriptions of the what you a are looking for.

downfall MW

2 : something that causes failure

In the end, gambling proved to be his downfall. [=ruin, undoing]

This refers to a specific aspect of a person/project/design/etc. that has most of the responsibility for its failure.

Typically the flaw or vice itself is described as the downfall, rather than someone "possessing" a downfall.

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