This question was sparked by considering the "word": pwn.
"Pawn" and "-pone" are both existing written form and vocalizations, but "pown" pronounced like "pone" is not a valid written form. It exists nowhere in English except for the modern term. In fact, I feel that it should be pronounced like "down" or "clown" with that written form.
Of course, it has it's origin as a mis-typing of "own" thus it may be natural to pronounce in "pone." However, pronunciation of words sort of evolves organically, and words generally have their origin in the vocal form.
How are we to decide on the pronunciation of a "word" that has its origin in written form (and not verbal communication), and more than that a written form that doesn't obey any of the natural rules of the vocal language?
This question could extend to any lol-speak "word" whose origin is in typed communication, e.g. saying "LOL" like "lull." I don't think it applies to constructed words that obey the rules of language, e.g. complicated technical jargon of academic fields. Such words are often derived from natural words, even if from a foreign language.