Once again, let poetry lead you to an answer.
A very well-known usage of sans appears in Shakespeare’s As You Like It, Act II, Scene VII: All the world’s a stage.
The lines describe the stages of a man’s life, and famously ends with the following:
Last scene of all,
That ends this strange eventful history,
Is second childishness and mere oblivion,
Sans teeth, sans eyes, sans taste, sans everything.
When you use sans in modern English, you are alluding to this work, either directly, or via some other writer that alluded to it earlier and perhaps more consciously.
Note the mood that it evokes: the lack of teeth etc. is the consequence of a fully-lived life. There can be self-awareness of the lacking, and a kind of wry humor. We are powerless to determine our lives, but we can find laughter in our responses, absurd though they may be.
So you can use sans in humorous writing aimed at an intelligent and well-read audience.
However, wry humor is something of an art, as these examples show.