In this sentence, which would be the better word to use, 'like' or 'as'?
"Chugging alcohol is like/as talking to God."
What would the difference be?
You can use like or as in comparisons, but they go with different grammatical follow-ups.
Like goes with nouns:
Chugging alcohol is like talking to G-d.
Similar works the same way but ironically emphasizes the distinction instead of the similarity.
Chugging alcohol is similar to talking to G-d [implied "but isn't the same thing"].
As goes with prepositional phrases and clauses:
Chugging alcohol makes people feel as if they were talking to G-d.
Chugging alcohol makes people feel as though they were talking to G-d.
There's also as ~ as, though, which takes nouns:
Chugging alcohol is as good as talking to G-d.
although that also emphasizes that they are noticeably distinct things. It's just that they are considered equally good by the speaker.
It is a comparison; one is looking for similarity.
Ergo, "like" applies, while "as" would be incorrect.