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I have no difficulty in normal cases knowing whether to say "you and I"or "You and me." But this situation confuses me. On one hand, I can justify I by saying there is an implied "are" at the end:

He is no different than you and I are

On the other hand, this is a comparative, and if I were to change the sentence up just a bit, it feels like it would be correct to say "me":

He is the same as me

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    It is ambiguous because 'than' can either act as a preposition or a comparative conjunction. So both options are valid.
    – user180089
    Jun 18, 2016 at 18:14
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    The analysis is problematic. The complement of the preposition "than" can either be analysed as an NP, an immediate constituent of "than", in which case "me" is correct. Alternatively, it could be seen as a reduced comparative clause where "I" is the subject: ...no different (to x) than you and I are different (to x).
    – BillJ
    Jun 18, 2016 at 18:50
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    I would say that if you are going to use different with than, it has to be followed by a clause and than is a conjunction; follow the same rule as for any clause. On the other hand, a comparative with than should be followed by a noun or pronoun object; however, I am old-fashioned and do not subscribe to the "different as comparative" style. Jun 18, 2016 at 18:51
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    Yes, but the complement of "different" has been ellipted. In full, it would be something like He is no different from the others than you or I/me
    – BillJ
    Jun 18, 2016 at 18:57
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    @BillJ I am not sure he had that in mind when he wrote it. There is a tendency in the US to use different as a comparative in the last 30 or 40 years. Personally I would also say different to or from. Jun 18, 2016 at 19:00

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