I have no difficulty in normal cases knowing whether to say "you and I"or "You and me." But this situation confuses me. On one hand, I can justify I by saying there is an implied "are" at the end:
He is no different than you and I are
On the other hand, this is a comparative, and if I were to change the sentence up just a bit, it feels like it would be correct to say "me":
He is the same as me