This question already has an answer here:
As an antonym for
exoticize, would you favor
Google currently finds ~2970 results for the hyphenated version and ~440 results for the unhyphenated, but both of those numbers are so small that I wouldn't call that conclusive.
An example sentence:
This novel deexoticizes/de-exoticizes Africa to the Western reader.
A general rule can be found at: When should compound words be written as one word, with hyphens, or with spaces? There, it is explained that prefixes are generally not hyphenated, but that there is a common exception of hyphenating prefixes when a vowel would be repeated otherwise. However, in this case, exoticize is a pretty stylized word, and I want to confirm that, in working with it, I should follow the same conventions as I would for more standard words.