For example ;

Ethical reasons such as religion, have a huge part in abortion.


Whether you need commas or not all depends on how important that information is in the phrase introduced by such as. That is, whether that phrase is restrictive or non-restrictive. In other words, is this information relevant for this sentence or not, would that sentence still make sense (also in context) if you leave it out.

Ethical reasons such as religion have a huge part in abortion.

If you write it like this you the reader would expect you to talk about religion in the following sentences. It is restrictive.

Ethical reasons, such as religion, have a huge part in abortion.

Here the focus lies on the ethical reasons with religion given as supporting example. It is non-restrictive.

To conclude, you either have a comma before such as and after the phrase introduced by it or no comma at all. It all depends on whether that information is important for the sentence and the following text or not.

If you ask uncle Google about "relative clause" you should find much info on restrictive and non-restrictive usage of clauses (Such as does not introduce a full clause; in your example it is part of a prepositional phrase). And finally, the Chicago manual of style even has some info on the comma usage with such as: Chicago Manual Of Style.

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