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I could not sleep ____ very tired .

Here, I tried:

  1. I could not sleep despite I was very tired .
  2. I could not sleep in spite of very tired

Which one is correct?

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There is a thread on this on the English Language Learners site, here.

Also, neither of these works in your sentence. You need to say "in spite of the fact that I was very tried" or "despite the fact that I was very tired".

You could also say "I could not sleep although I was very tired".

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