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Splicing factors have oncogenic properties. However, their expression patterns and practical priority in gastric cancer and the difference of them between gastric cancer and colorectal cancers are unknown.

I'm not a native speaker. In the sentence, the intended meaning of "them" is "their expression patterns and practical priority". If I use them, is it odd? What word should I use. If I use those instead of them, it it right? Please let me know the word (one word, if possible) that could indicate "their expression patterns and practical priority"

4 Answers 4

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The expression 'the difference of them' is very odd in English and should be replaced by 'their difference'.

However neither of the above expresses your meaning because 'them' and 'their' refer to 'splicing factors'.

I suggest a complete rewrite of the sentence.

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Your first paragraph seems to have been written by a NNES. As far as I can understand it, the writer seems to mean:

Splicing factors have oncogenic properties. However, their expression patterns and practical priority in gastric cancer, and the differences between their action in gastric and colorectal cancer are unknown.

To me "their action" refers to "splicing factors".

4
  • South Eastern Freight Lines??
    – Hot Licks
    Aug 5, 2015 at 4:14
  • @HotLicks Speaker of English as a foreign language.
    – Centaurus
    Aug 5, 2015 at 14:34
  • Several acronym sites could not identify it.
    – Hot Licks
    Aug 5, 2015 at 16:49
  • @HotLicks My bad. I should've been NNES.
    – Centaurus
    Aug 5, 2015 at 23:43
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If I understand your second sentence correctly -

However, their differences in expression patterns and practical priorities between gastric and colorectal cancers are unknown.

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" ...and differences thereof...."

thereof refers to whatever things were immediately preceeding.

No no no.... ignore that^^

After further review, I believe you are listing a series of things which are unknown.

However, their expression patterns, practical priority in gastric cancer, and the differences thereof in gastric cancer and colorectal cancers are unknown.

Maybe

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