"to become comatose with pleasure"
(i.e. where you experience so much euphoria that you literally become incapable of movement)?
I think ecstatic may suggest the "comatose-like" state you are referring to:
- in a trancelike state of great rapture or delight. (Collins Dict.)
I have been narcotized with pleasure:
a : to treat with or subject to a narcotic
b : to put into narcosis
2 : to soothe to unconsciousness or unawareness
This assumes the secondary meaning of comatose:
1.1 humorous Extremely lethargic or sleepy:
she lay comatose in the sun listening to a personal stereo
I remember a time when I was experiencing some scary chest pains. After the doctor ruled out a heart attack, he decided morphine was the best temporary treatment--until they could get at the root of the problem. What a pleasant experience I had, but it was always so short lived, because I was so relaxed I fell asleep!
Any pleasure has the potential to become a narcotic for the human mind:
1 An addictive drug affecting mood or behavior, especially an illegal one:
If we overload on any mind-altering activity, we loose touch!
From the poem Narcotized in A Whole Bunch of Words by Jon Glenn:
The early morning sun shines in through a dusty basement window. Now that the night is gone, my day can go on like the last one. I get up on my world, I feel like I slept on pins and needles. The air is cold and damp; I careen By way of my perception...
I drift along in a daze; I feel as if I have been narcotized. I remember the way as I regress in to a photograph.