Technically to defenestrate means to remove a window, or better, to break a pane of glass, but no English speaking person ever uses it in this manner. Fenestration is certainly an architectural term referring to windows, usually in buildings of historical interest, i.e. 'the fenestration is essentially gothic'. The only sense in which the term is commonly used in English is a colloquial one, meaning to take a woman's virginity, and likens breaking a pane of glass to breaking a hymen. 'To defenestrate' has never meant 'to throw someone out of a window'.