While 'Knocked Up' doesn't usually refer to 'Made Tired/Worn Out', this might be somewhat relevant to what you're looking for- "primary meaning of Knocked Up". As you will see, the phrase 'Knocked Up' has different primary meanings over different geographical areas.
In short, other than the primary meaning we all know, here are the other(relatively less used) meanings you're looking for(cited from the above link)-
This is a difference between American and British English. In England
if you knock someone up you get them out of bed
Knock up is 1660s in sense of "arouse by knocking at the door;"
however it is little used in this sense in Amer.Eng., where the phrase
means "get a woman pregnant" (1813)....
-Online Etymology Dictionary