See the discussion referenced by @FumbleFingers for views on the general appropriateness of the term off of.
As to whether it can be substituted for from depends on context.
The term off of suggests that something is being obtained or moved.
I got that data off of the internet.
They took the book off of the shelf.
In these cases, from would be equally appropriate (and for many, preferable).
I got that data from the internet.
They took the book from the shelf.
When referencing something's place of origin, but not suggesting duplicating or moving, from can be used, but off of would sound off.
That character is from the Friends TV show.