I was watching a TED talk on cartoons in The New Yorker, and the presenter used an idiom I've never heard.
But like I said, you cannot satisfy everyone. You couldn't satisfy this guy.
"Another joke on old white males. Ha ha. The wit. It's nice, I'm sure to be young and rude, but some day you'll be old, unless you drop dead as I wish."
The New Yorker is rather a sensitive environment, very easy for people to get their nose out of joint.
In this context it is easy to see that means to get someone annoyed or bothered (similar to "knickers in a twist" or "panties in a bunch".)
I'm just curious as to where it's come from and when/where the popular use is, as I've never heard it before. I'm 23 and live in PA.