I have been asked one simple question many times by Americans: "How are you?". I know this does not mean that the person I am talking to wants to know how I feel, but sometimes I see that they repeat the question to me, so I answer that "I am fine", and I do not know what I should answer other than "fine" to people who I do know.
I know, for example, that in Hebrew "How are you?" in most cases means "Hello". In Russian if you ask "How are you?" you definitely want to know it.
What do you mean when you ask this question? What answer do you want to hear?