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From Flappers to Rappers, a book of American youth slang, records "Priscilla" as a 1920s slang word for a girl who prefers to stay home.
I'm curious to know why the author chose that name. Is there a historical figure named Priscilla who might plausibly be the archetype for a female who doesn't like to venture out?
The name seems to have an actual etymology that fits your question
fem. proper name, from Latin, fem. of Priscillus, diminutive of Priscus, from priscus "antique, old-fashioned, old, ancient, primitive, venerable;"
Other names may just get associated with something due to who was given them, viz, "Sharon" being considered a low class British girl (chav)
Priscilla is a name from the New Testament. Priscilla and her husband Aquila were among the first generation of Christians. They hosted Christian worship services in their home in Pontus, which is on the Black Sea in what is now Turkey. Priscilla has a connotation of "homebody", one who offers generous hospitality.
Reference: 1 Corinthians 16:19 King James Version: The churches of Asia salute you. Aquila and Priscilla salute you much in the Lord, with the church that is in their house.
I'd be much more inclined to consider the similarity between Priscilla (often shortened to Prissy) and prissy "fussy and excessively respectable".
