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Is there any link between affection and affectation, especially in terms of etymology? I understand -fect means something like "make". Does "make" play any role in conveying their distinct meanings?

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The word affectation has roots going back to a Latin verb affectare for "to strive for, or pretend" and had a meaning in rhetoric no very unlike the modern one of trying too hard. Affection goes back to Latin afficere, meaning "to have an effect on." (The transition from influence to feeling occurred when being passed through French and Middle English.) Affectare derives from affectus, past participle of "afficere," so yes.

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