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Dec 3, 2012 at 18:01 comment added tchrist @MrLister Yes, certainly. The idea is simply that if it is something whose case you cannot change, then you must not put it first in a sentence. There are many workarounds, but not starting the sentence with a capital letter is not one of them.
Dec 3, 2012 at 17:47 comment added Mr Lister Is this also a problem for physical quantities like mV (millivolt) versus MV (megavolt)?
Dec 3, 2012 at 16:19 comment added user21497 You make a good point about recasting the sentence to avoid scorn for starting out with a minuscule instead of a majuscule. Thank goodness for me that the biomedical world doesn't wholeheartedly agree with that dictum (eg, "p38α phosphorylates serine 258...". mRNA, as nico pointed out (see J.R.'s comment above) just isn't ever written as MRNA, & Wikipedia starts sentences with proper names like "eBay". In biomed-speak, change the case & you might just change the meaning.
Dec 3, 2012 at 16:04 history answered tchrist CC BY-SA 3.0