Actually, it is navigation in general sense.

Travel or traffic by vessels, especially commercial shipping.

But in colloquial speech, you cannot say "My navigation is at 2:00pm."

In your example, you mean the "scheduled time" sense of the word. In my opinion, there is not a specific word that covers all scheduled times of all water travels that can substitute "flight" in your example.

One of the answers mentioned sailing, which has a dictionary definition in this sense but it does not sound right when you say "My sailing is at 2:00 pm".

You would use general words or rephrase what you want to say. For example, you can use departure.

My departure is at 2:00 pm

Just to be more specific, you might say "departure from the seaport". Though not all water travels start from a seaport.

Actually, it is navigation in general sense. (for answering the question title)

Travel or traffic by vessels, especially commercial shipping.

But in colloquial speech, you cannot say "My navigation is at 2:00pm."

In your example, you mean the "scheduled time" sense of the word. In my opinion, there is not a specific word that covers all scheduled times of all water travels that can substitute "flight" in your example.

One of the answers mentioned sailing, which has a dictionary definition in this sense but it does not sound right when you say "My sailing is at 2:00 pm".

You would use general words or rephrase what you want to say. For example, you can use departure.

My departure is at 2:00 pm

Just to be more specific, you might say "departure from the seaport". Though not all water travels start from a seaport.