It's certainly poor style, if not actually wrong, to join independent clauses with a comma when a semicolon or other punctuation would have sufficed. But interjections are usually offset from other ...
Is this a comma splice? What makes a sentence a comma splice? Being left at the altar on her wedding day, Pamela became furious.
I've been trying to find an answer to this question for some time, and have finally decided to... well, buck up some courage and ask. In sentences like these two "Hello, Mary, how are you?" ...