I have heard this many times, with variations like "something's gotta give", but what exactly does it mean?
closed as general reference by MετάEd, Mitch, Mark Beadles, Matt Эллен, J.R. Oct 18 '12 at 15:09
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From the Macmillan Dictionary entry for give:
"Something's gotta give" means that things are building up and the speaker expects that whatever is supporting everything is going to break under the pressure. This can be (and often is) used figuratively.