Safe means that the condition is protected.
Car safety = safety belt, airbar, etc.
Secure means only people allowed by the owner are able to access it.
Car security = lock, alarm, gps tracking, etc.
Secure means it cannot be stolen. Like passwords, or money.
Safe means it cannot be destroyed. Like health.. Or a painting is safer in the right conditions, like perfect humidity...
Safe location = you will not be killed here.
Secure location = you will not overheard here. It's OK, to talk.
If both is important, or we talk about organizations, we usually use the word security. Airport secutiry, building secutirty, national security, secure location (in military... it means safe too)