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I am not sure if 2X is even a valid word.

What are the proper usages for each of the three?

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Firstly, they all mean exactly the same.

2X is used informally and sometimes in technical writing as a convenient abbreviation to avoid verbosity.

2 times highlights the number 2 and may be used to standardise writing instead of using the special twice if there are other numbers involved (5 times, 8 times).

Twice is most succinct in ordinary non-technical writing.

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And then there's always . – RegDwigнt Jan 4 '12 at 19:59

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