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Consider:

Childhood never comes again in life.

What might be single word that means never come again in life?

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marked as duplicate by Urbycoz, Robusto, Shog9 Jul 10 at 14:09

This question has been asked before and already has an answer. If those answers do not fully address your question, please ask a new question.

    
What part of speech are you looking for? Noun? Adjective? –  Robusto Jul 10 at 13:58
    
In my opinion, it was not a duplicate even it leads to the same answers. –  ermanen Jul 10 at 14:16

3 Answers 3

up vote 4 down vote accepted

There is one-off in BrE.

1. adj. Happening, done, or made only once.
2. n. Something that is not repeated or reproduced.

Source:http://www.thefreedictionary.com/one-off

Example: (from the book "Global Citizenship and the Legacy of Empire: Marketing Development" By April Biccum)

Childhood is a one-off window of development, which makes investing in children a priority but not a choice. Damage at this stage cannot be overcome later in life. Northern child poverty is the root of the most serious social problem facing these countries in the future.

(Wilkinson, 2000, p. 17, my emphasis)

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one-off is the best match. –  vickyace Jul 10 at 13:58

Quoth the Raven “Nevermore.” - E. A. Poe

The word you are looking for is nevermore:

never again; never thereafter: And nevermore were the elves seen in that town.

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The expression once-in-a-lifetime may fit:

  • Describes an experience or opportunity that is very special because you will probably only have it once : A tour of Australia is a once-in-a-lifetime experience .

  • A chance that will never occur again in one's lifetime. This is a once-in-a-lifetime chance. Don't miss it. She offered me a once-in-a-lifetime opportunity, but I turned it down.

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